An Ultra-Sensitive Molecularly Imprinted Poly(Aniline) Based Electrochemical Sensor for the Determination of Bisphenol A in Synthetic Human Serum Specimen and Plastic Bottled Water Samples

We explain the development of an ultra-sensitive molecularly imprinted polymer-based electrochemical sensor for rapid and selective determination bisphenol A (BPA) in human serum water samples. Electropolymerization functional monomer aniline was performed presence BPA by cyclic voltammetry (CV) to prepare a poly(aniline) based GCE (MIP(ANI)/GCE). The developed MIP surface characterized using Fourier-transform infrared spectroscopy, Raman spectrometry, scanning electron microscopy, contact angle measurements, CV, impedance spectroscopy. MIP(ANI)/GCE showed highly sensitive performance with linear range 1.0 8.0 × 10 ?15 M. limit detection (LOD) quantification (LOQ) values were 0.193 0.643 fM, respectively. applicability assessed applying it plastic bottled LOD LOQ calculated as 0.257 0.856 fM sample. Imprinting factor interference studies also carried out similarly structured compounds most common interfering agents showing selectivity sensor. Finally, non-imprinted polymer (NIP)-based prepared control performance.